The Al Attiyah October 23 paper discusses the relevance of regional cooperation for tackling climate change impacts in the Middle East and North Africa (MENA) region. The paper presents the different climate hazards (e.g. droughts, rising sea levels and extreme weather events) and corresponding impacts affecting the region. It highlights the fact that despite the growing challenges, regional collaborative efforts remain limited, particularly for tackling slow onset events like aridification. Through different case studies on successful regional cooperations (the Islamic Development Bank, the West African Climate Alliance on Carbon Markets and Climate Finance, and the Sahara and Sahel Observatory), the paper describes how regional collaborations can strengthen the work on climate change adaptation and resilience through finance mobilization, knowledge and technology exchange, policy/strategies harmonisation, and increasing the region’s influence in international discussions. It argues for the importance of regional cooperation for leveraging the collective strengths, knowledge, and values of different stakeholders, which are particularly relevant for addressing slow onset events like aridification.